基于CDEGS软件设计的下水库接地网改造

本文利用CDEGS软件,对天荒坪抽水蓄能电站水库区域的土壤及岩石等地质参数进行分析和拟合,并构建土壤的分层模型;然后通过对地网的网格大小、导体的疏密程度、接地网的面积、水平接地体的长度等因素进行经济比较和优化分析,设计出了符合安全标准的水下接地网。结果表明:水下接地网的设计满足设计要求,达到了改善接地网参数性能的目标。     

DPZ1型综合集成硬件控制器硬件安装与软件调试

文章重点介绍了DPZ1型综合集成硬件控制器的硬件组成、安装与连接的步骤方法以及注意事项。对底层软件安装及调试作了详细的说明,对于在安装与使用过程中出现的问题以及需要注意的事项,提出了相应的解决方法。对底层驱动程序安装调试过程中出现的问题提供了实用的解决方法,为业务人员提供参考。     

New Insights into the Pathogenesis of Systemic Mastocytosis

Mastocytosis is a type of myeloid neoplasm characterized by the clonal, neoplastic proliferation of morphologically and immunophenotypically abnormal mast cells that infiltrate one or more organ systems. Systemic mastocytosis (SM) is a more aggressive variant of mastocytosis with extracutaneous involvement, which might be associated with multi-organ dysfunction or failure and shortened survival. Over 80% of patients with SM carry the KIT D816V mutation. However, the KIT D816V mutation serves as a weak oncogene and appears to be a late event in the pathogenesis of mastocytosis. The management of SM is highly individualized and was largely palliative for patients without a targeted form of therapy in past decades. Targeted therapy with midostaurin, a multiple kinase inhibitor that inhibits KIT, has demonstrated efficacy in patients with advanced SM. This led to the recent approval of midostaurin by the United States Food and Drug Administration and European Medicines Agency. However, the overall survival of patients treated with midostaurin remains unsatisfactory. The identification of genetic and epigenetic alterations and understanding their interactions and the molecular mechanisms involved in mastocytosis is necessary to develop rationally targeted therapeutic strategies. This review briefly summarizes recent developments in the understanding of SM pathogenesis and potential treatment strategies for patients with SM.     

Some Molecular and Cellular Stress Mechanisms Associated with Neurodegenerative Diseases and Atherosclerosis

Chronic stress is a combination of nonspecific adaptive reactions of the body to the influence of various adverse stress factors which disrupt its homeostasis, and it is also a corresponding state of the organism’s nervous system (or the body in general). We hypothesized that chronic stress may be one of the causes occurence of several molecular and cellular types of stress. We analyzed literary sources and considered most of these types of stress in our review article. We examined genes and mutations of nuclear and mitochondrial genomes and also molecular variants which lead to various types of stress. The end result of chronic stress can be metabolic disturbance in humans and animals, leading to accumulation of reactive oxygen species (ROS), oxidative stress, energy deficiency in cells (due to a decrease in ATP synthesis) and mitochondrial dysfunction. These changes can last for the lifetime and lead to severe pathologies, including neurodegenerative diseases and atherosclerosis. The analysis of literature allowed us to conclude that under the influence of chronic stress, metabolism in the human body can be disrupted, mutations of the mitochondrial and nuclear genome and dysfunction of cells and their compartments can occur. As a result of these processes, oxidative, genotoxic, and cellular stress can occur. Therefore, chronic stress can be one of the causes forthe occurrence and development of neurodegenerative diseases and atherosclerosis. In particular, chronic stress can play a large role in the occurrence and development of oxidative, genotoxic, and cellular types of stress.     

Sensei: Enforcing secure coding guidelines in the integrated development environment

We discuss the potential benefits, requirements, and implementation challenges of a security-by-design approach in which an integrated development environment plugin assists software developers to write code that complies with secure coding guidelines. We discuss how such a plugin can enable a company's policy-setting security experts and developers to pass their knowledge on to each other more efficiently, and to let developers more effectively put that knowledge into practice. This is achieved by letting the team members develop customized rule sets that formalize coding guidelines and by letting the plugin check the compliance of code being written to those rule sets in real time, similar to an as-you-type spell checker. Upon detected violations, the plugin suggests options to quickly fix them and offers additional information for the developer. We share our experience with proof-of-concept designs and implementations rolled out in multiple companies, and present some future research and development directions.     

基于过程与场景分析的航天应用软件测试方法

航天应用软件系统具有软件种类多、规模大、信息交换关系复杂等特点，如何开展软件测试是工程实践中的一个难题。结合某测控信息应用软件系统实例，提出了一种基于形式化模型的软件系统测试方法。基于软件系统形式化定义和线索分析技术，绘制软件系统运行流程图、阶段分析图，建立可表述软件系统级行为的场景树模型和场景树图；根据测试充分性要求，提出基于场景树图的路径覆盖准则，给出满足路径覆盖准则的测试用例集自动化生成算法；结合工程实例，给出了方法应用数据，开展测试结果分析。验证结果表明该测试方法是可行的和有效的，能够保障软件测试的充分性。     

水电工程下泄生态基流常用计算方法及软件开发

为了分析及确立生态基流,为水电工程环境影响评价提供依据,针对水电工程生态基流估算及决策过程繁复等问题,以2001—2015年水电工程环境影响评价及相关法律法规为基础,分析我国生态基流管理实践中使用最广泛的4种计算方法,即Tennant法、月基本流量法、最小流量法及7Q10法,并编制生态基流决策支持软件,并应用软件在汉江流域进行实例验证。结果表明,该软件能够提供多种计算方法及对比分析功能,可为水电工程下泄生态基流计算及决策提供计算平台。4种计算方法在汉江流域计算结果差异较大。总体而言,干流适合最小流量法及Tennant法,支流适合Tennant法。研究成果具有较大的实际应用和推广价值。     

Interventions for long-term software security: Creating a lightweight program of assurance techniques for developers

Though some software development teams are highly effective at delivering security, others either do not care or do not have access to security experts to teach them how. Unfortunately, these latter teams are still responsible for the security of the systems they build: systems that are ever more important to ever more people. We propose that a series of lightweight interventions, six hours of facilitated workshops delivered over three months, can improve a team's motivation to consider security and awareness of assurance techniques, changing its security culture even when no security experts are involved. The interventions were developed after an Appreciative Inquiry and Grounded Theory survey of security professionals to find out what approaches work best. We tested the interventions in a participatory action research field study where we delivered the workshops to three software development organizations and evaluated their effectiveness through interviews beforehand, immediately afterwards, and after twelve months. We found that the interventions can be effective with teams with limited or no security experience and that improvement is long-lasting. This approach and the learning points arising from the work here have the potential to be applied in many development teams, improving the security of software worldwide.     

能源互联网内多类设备协同运行的能量管理系统软件设计

针对能源互联网中的海量分布式设备和电动汽车的需求，利用C#和Java编程语言设计并开发面向能源互联网的能量管理系统。该系统采用典型B/S 架构，以Asp.Net动态网页开发技术和数据库技术为核心，由云端后台算法、云端服务器的MySQL数据库、前端的网页三大部分构成。详细介绍了软件平台的系统框架，分为上下两层。其中，上层为日前-实时协同的多时间尺度能量管理系统模块，下层包含分布式设备协调控制子系统和电动汽车协调控制子系统。最后，通过仿真算例分析，能量管理系统能对海量的分布式设备和电动汽车进行优化调度，验证了该软件的可移植性、有效性和实用性。     

基于ISIGHT的安全气囊盖板结构优化设计方法研究

选取某款弱化沟槽呈“H”形的聚碳酸酯/丙烯腈?丁二烯?苯乙烯共聚物(PC/ABS)合金材质安全气囊盖板为研究对象，并构建了其有限元仿真模型，对比有限元力学仿真分析结果与理论计算值验证了该有限元仿真模型的可靠性；通过ISIGHT软件集成Catia和ANSYS，选取安全气囊盖板弱化沟槽的横向长度、深度，纵向长度、深度4个参数作为设计变量，选取弱化沟槽横向最大应力与纵向最大应力作为响应变量，分析了设计变量对响应变量的贡献度分布特征并采用NSGA遗传算法对响应变量多目标优化。结果表明,横向长度、纵向深度对横向最大应力为负贡献度，横向深度、纵向长度为正贡献度；横向深度、纵向长度对纵向最大应力为负贡献度，横向长度、纵向深度为正贡献度；在合理范围内，4个参数值的优化设计，实现了横向最大应力提高和纵向最大应力降低的多目标优化，有效减少了安全气囊盖板爆破时产生的碎屑量，提升了产品的安全性能。